Bioorganic and Organic Reactivity


Project Description

Bioorganic and organic reactivity is examined using analytical methods, including computational chemistry and mass spectrometry.  Specific projects include the study of damaged DNA, carbene reactivity, and catalysis.

Qualifications

GPA:  > 3.5
Course Experience: Ideally both semesters of organic though particularly strong students have started as early as freshman year

Current Undergraduate Researchers

  • Aaron Petronico
  • Jimmy Patel
  • Julianne Davis

Publications with Undergraduate Co-authors

Michelson, A. Z.; Petronico, A.  "2-Pyridone and Derivatives: Gas Phase Acidity, Proton Affinity, Tautomer Preference and Leaving Group Ability," J. Org. Chem., 2012, 77, 1623-1631.

Rozenberg, A; Lee, J. K. "Theoretical Studies of the Quinolinic Acid to Nicotinic Acid Mononucleotide Transformation," J. Org. Chem., 2008, 73, 9314-9319.

Pan, S.; Verhoeven, K.; Lee, J. K. "Investigation of the Initial Fragmentation of Oligodeoxynucleotides in a Quadrupole Ion Trap: Charge Level-Related Base Loss," J. Am. Soc. Mass Spectrom. 2005, 16, 1853-1865.

Schulze, S. M.; Santella, N.; Grabowski, J. J., Lee, J. K.  "The Anionic Oxy-Cope Rearrangement:  Using Chemical Reactivity to Reveal the Facile Isomerization of the Parent Substrates in the Gas Phase," J. Org. Chem.  2001, 66, 7247-7253.

Research Area: 
Biological
Organic
Physical
Theory